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Eriodictyol reduced oxidative damage, prevented cell apoptosis, induced glutathione synthesis, and reduced ROS production in H 2 O 2 -treated PC12 cells ( 3.6 Modulation of intestinal microbiota The enteric nervous system (ENS) is known to control gastrointestinal behavior via the actions of neurons and neurotransmitters in a manner independent of central nervous system (CNS) input, thereby also known as the “second brain” ( via increasing the level of beneficial bacteria and decreasing the inflammatory bacteria in CUMS mouse ( 3.7 Regulation of ferroptosis Ferroptosis describes iron-mediated oxidative cell death, largely due to the toxicity from dramatical increase in the level of intracellular iron ions ( Alpinia officinarum , also inhibited ferroptosis in the hippocampus by activating the SLC7A11/GPX4 axis ( 3.8 Pathway enrichment analysis The potent active compounds were further examined through network pharmacology analysis while the target proteins were accordingly predicted (Figures 3, 4)
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This ultimately results in loss of feedback inhibition and increased production of 5-oxoproline from its precursor gamma glutamylcysteine